Detection of T315I Mutation in Ph+ Leukemias: Clinical Insights from One Case Report

نویسندگان
Jaramillo Jaramillo, Carolina ID 1
Pérez Mejía, Juliana ID 2
Rave Zapata, Sara María ID 3
Villa Palacio, Maria Isabel ID 4
Velasco Cardona, Diana Carolina ID 5

1 School of Bacteriology, Colegio Mayor de Antioquia, Colombia.

2 Health Sciences, Colegio Mayor de Antioquia, Colombia.

3 Antioquia, Colegio Mayor de Antioquia, Colombia.

4 Faculty of Health Sciences, Colegio Mayor de Antioquia, Colombia.

5 Health Sciences, Colegio Mayor de Antioquia, Colombia.

doi
10.61882/ijbc.17.3.5
چکیده

The reciprocal translocation between chromosomes 9 and 22, known as the Philadelphia chromosome, results in the formation of the BCR/ABL fusion gene. This genetic aberration leads to dysregulation of intracellular kinase activity. The detection of the Philadelphia chromosome is a critical component of the diagnostic evaluation of myeloproliferative neoplasms and acute lymphoid ...

کلیدواژه‌ها
Chronic myeloproliferative neoplasm, Philadelphia chromosome, BCR/ABL.