Digging deep into molecular pathways: Investigating the effects of 9S-HOD on leukemia cells using a systems biology approach

نویسندگان
Zamanian Azodi, Mona ID 1
Razzagh, Zahra ID 2
Arjmand, Babak ID 3
Rostami Nejad, Mohammad ID 4
Mansouri, Vahid ID 5
M Robati, Reza ID 6
Rezaei Tavirani, Mostafa ID 7

1 Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

2 Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

3 Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. and Iranian Cancer Control Center (MACSA), Tehran, Iran

4 Celiac Disease and Gluten Related Disorders Research Center, Research Institute for Gastroenterology and Liver Disease, Shahid Beheshti University of Medical Sciences, Tehran, Iran

5 Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

6 Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

7 Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

doi
10.61186/ijbc.15.4.253
چکیده

Background: Acute myeloid leukemia (AML) is a malignant disorder characterized by a poor prognosis. Current therapeutic approaches include chemotherapy, steroids administration, and blood transfusion. Previous studies have highlighted the potential anticancer property of 9-hydroxyoctadecadienoic acid (9S-HOD). This molecular computational research aims to investigate the intricate molecular mechanism underlying the effects of 9S-HOD ...

کلیدواژه‌ها
9-hydroxyoctadecadienoic acid (9S-HOD), Leukemia cells, Protein-protein interaction network analysis, Centrality, Gene ontology.