Efficacy of Deferasirox through Bioequivalence Study in Indonesian Healthy Volunteer

نویسندگان
Paramanindita, Asti Swari ID 1
Wijayanti, Tri Rahayu ID 2
Lusthom, Windy ID 3
Widjaja, Evan ID 4
Puspanegara, Girinanda ID 5
Harahap, Yahdiana ID 6
Prasaja, Budi ID 7
Sandra, Monika ID 8

1 P.T. Clinisindo Laboratories, Jakarta, Indonesia

2 P.T. Clinisindo Laboratories, Jakarta, Indonesia

3 P.T. Clinisindo Laboratories, Jakarta, Indonesia

4 Faculty of Pharmacy, University of Indonesia, Depok

5 P.T. Novell Pharmaceutical Laboratories, Jakarta, Indonesia

6 Faculty of Pharmacy, University of Indonesia, Depok

7 Faculty of Pharmacy, University of Indonesia, Depok

8 P.T. Clinisindo Laboratories, Jakarta, Indonesia

doi
چکیده

Background: Deferasirox is an orally bioavailable synthetic, tridentate iron chelator that binds iron at a 2:1 ratio. The generic brand for this drug is still not available in Indonesia. We aimed to compare the efficacy between the generic drug and its innovator (Exjade®) by a study of bioequivalence in Indonesia among healthy ...

کلیدواژه‌ها
Thalassemia major, Deferasirox, Bioequivalence, Iron chelation, Pharmacokinetics