Factor V Leiden, MTHFR C677T and Prothrombin Gene Mutation G20210A in Iranian Patients with Venous Thrombosis

نویسندگان
Hamidpour, Mohsen ID 1
Ghorbani, Mohammad ID 2
Rezaei-Tavirani, Mostafa ID 3
Niazkar, Hamid Reza ID 4
Managhchi, Mohammad Reza ID 5
Shahrudian, Masoud ID 6

1 PhD in Hematology, Department of Hematology & Blood Banking , School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

2 MSc of Hematology and Blood Banking, Faculty member of Gonabad University of medical sciences, Gonabad, Iran.

3 Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran

4 Medical Student, Student Research Committee, Gonabad University of Medical Sciences, Gonabad, Iran

5 Msc in Hematology and oncology, Thrombosis Disease Research Center, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran

6 Doctor of Clinical laboratory scienses, Sarvar Clinic laboratory, Mashhad

doi
چکیده

Background: Factor V Leiden, Prothrombin gene (G20210A) and MTHFR (C677T) polymorphism are the main biomarkers for evaluation of tendency for venous thromboembolism. We aimed to investigate the frequency of mutations in factor V Leiden, Prothrombin G20210A and MTHFR C677T and identify the genetic status for these mutations in patients with venous thrombosis. ...

کلیدواژه‌ها
Venous thromboembolism, Factor V leiden, MTHFR C677T, Prothrombin G20210A, PCR-RFLP method