TPMT and ITPA Gene Polymorphism and Their Adverse Events during Chemotherapy of Acute Lymphoblastic Leukemia among Bangladeshi Children

نویسندگان
Fukushima, Hiroko ID 1
Suzuki, Ryoko ID 2
Yoshimatsu, Shoji ID 3
Zaman, Sanjana ID 4
Hawlader, Mohammad Delwer Hossain ID 5
Fukushima, Takashi ID 6

1 University of Tsukuba

2 Department of Child Health, Graduate School of Comprehensive Human Sciences Majors of Medical Sciences, University of Tsukuba

3 Research Institute of Tuberculosis, Tokyo

4 North South University

5 North South University

6 University of Tsukuba

doi
چکیده

Background: The pharmacogenetic-oriented approach reduces the toxicity and increases the safety of chemotherapeutic agents. 6-mercaptopurin (6-MP) metabolizing enzymes such as thiopurine S-methyltransferase (TPMT) and inosine triphosphate pyrophosphatase (ITPA) contribute to variable responses and adverse effects among leukemia patients treated with 6-MP. The aim of our study was to identify the ...

کلیدواژه‌ها
TPMT gene polymorphisms, ITPA enzyme, Polymorphism, Acute lymphoblastic leukemia, Children, 6-mercaptopurine toxicity