Dysregulation of the WNT Signaling Pathway Through Methylation of Wnt Inhibitory Factor 1 and Dickkopf-1 Genes among AML Patients at the Time of Diagnosis

نویسندگان
A, Ghasemi ID 1
A, Ghotaslou ID 2
M, Mohammadi ID 3
K, Ghaffari ID 4
S, Abbasian ID 5

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چکیده

Background: In acute myeloblastic leukemia, a large number of tumor suppressor genes are silenced through DNA methylation such as CDKN2B & p73. Wnt inhibitory factor 1 (WIF1) and Dickkopf-3 (DKK-1) are negative regulators of Wnt signaling pathway. In the present study, we evaluated the methylation status of WIF1 and DKK-1 genes in ...

کلیدواژه‌ها
AML, Wnt inhibitory factor 1, dickkopf, DNA methylation.