Deferoxamine Protective Effect in Preventing Nephrotoxicity in Children Under Treatment with Doxorubicin: A Randomized Clinical Trial

نویسندگان
Bordbar, Mohammadreza ID 1
Saleh, Fazl ID 2
Zekavat, Omid Reza ID 3
Basiratnia, Mitra ID 4
Shahriari, Mahdi ID 5
Fathpour, Gholamreza ID 6
Zareifar, Soheila ID 7
Karimi, Mehran ID 8
Shakibazad, Nader ID 9

1 Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

2 Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

3 Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

4 Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

5 Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

6 Bushehr University of Medical Sciences, Bushehr, Iran

7 Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

8 Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

9 Assistant Professor of Pediatric Hematology and Oncology, Bushehr University of Medical Sciences, Bushehr, Iran

doi
چکیده

Background: Nephrotoxicity secondary to doxorubicin (DOX) may be associated with high morbidity and mortality rates. We aimed to assess the efficacy of Deferoxamine (DFO) in preventing DOX-induced nephrotoxicity in pediatric malignancy. Methods: This Parallel-group randomized clinical trial was done on 62 children aged 2-18 years who had new onset malignancy ...

کلیدواژه‌ها
Deferoxamine, Doxorubicin, N- Acetyl -β -D- Glucosaminidase, Nephrotoxicity