Taq1 Polymorphism (rs731236) of Vitamin D Receptor Gene in Children with Acute Lymphoblastic Leukemia

نویسندگان
Mortazavi, Yousef ID 1
Ale Ahmad, Atiyeh ID 2
Saburi, Ehsan ID 3
Rajaei, Toktam ID 4

1 Department of Nanotechnology and Biotechnology, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran

2 Health Research Institute, Babol University of Medical Sciences, Babol, Iran 2. Student Research Committee, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran

3 Department of Genetics and Molecular Medicine, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran

4 Department of Parasitology and Mycology,Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran

doi
چکیده

Background: Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. Several studies have shown that ALL occurs as a result of genetic abnormalities. 1, 25-Dihydroxyvitamin D3 as a secosteroid hormone plays an important role in different metabolic pathways. The normal function of vitamin D occurs via binding to a ligand-activated transcription factor i.e. ...

کلیدواژه‌ها
Acute lymphoblastic leukemia, rs731236, Single nucleotide polymorphism (SNP), TaqI, Vitamin D receptor