Optimized Cytoplasmic Expression of Water Soluble Human Thrombopoietin in Modified Bacterial Strain
نویسندگان
1 Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine
2 Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine
3 Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine
4 Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine
doi
چکیده
Background: Thrombopoietin is a glycoprotein produced by liver and kidney which is responsible for regulating the platelet production. Thrombopoietin is a key ligand with impact on regulating the self-renewal of Hematopoietic stem cells and the regulation of Megakaryocytes progenitors. Previous studies have indicated that only N-terminal domain of this protein has receptor ...
