Sub-acute Exposure to Benzene Accelerates the Aging Process of Red Blood Cells; an In vivo Study

نویسندگان
Mostafavi, Mohammad-Amin ID 1
Karami-Mohajeri, Somayyeh ID 2
Pudineh Moarref, Mokarameh ID 3
Safavi, Moeinadin ID 4

1 Department of Toxicology and Pharmacology, Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran

2 Department of Toxicology and Pharmacology, Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran

3 Department of Toxicology and Pharmacology, Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran

4 Department of Pathology, Afzalipour Medical Faculty, Kerman University of Medical Sciences, Kerman, Iran

doi
چکیده

Background: The well-known toxic effects of benzene toxicity are bone marrow depression, reduction in blood cell counts, and induction of leukemia and aplastic anemia. This study was designed to evaluate biomarkers of aging in red blood cells (RBCs). Methods: Mice were exposed to benzene (50, 100, and 200 mg/kg/day) orally ...

کلیدواژه‌ها
erythrocyte, senescence, oxidative stress, sialic acid, sub-acute toxicity