Comparison of Secreted Frizzled-Related Protein -4 & -5 Promoter Methylation in Patients with Acute Myeloblastic Leukemia and Healthy Individuals

نویسندگان
Ghaffari, Kazem ID 1
Abbasian, Sadegh ID 2
Ghasemi, Ali ID 3
Mohammadi, Mohsen ID 4

1 Department of Laboratory Sciences, Khomein University of Medical Sciences, Khomein, Iran

2 Blood Transfusion Research Center, High Institute for Research & Education in Transfusion Medicine,Tehran, Iran

3 Department of Biochemistry and Hematology, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran

4 The Persian Gulf Marine Biotechnology, Medicine Research Center, Bushehr University of Medical Sciences, Bushehr, Iran

doi
چکیده

Background: DNA methylation patterns are often changed in cancer cells. Many of the tumor inhibitor genes are silenced by methylation, such as CDKN2B, p73, and the suppressor of cytokine signaling in patients with acute myeloblastic leukemia (AML). Secreted frizzled-related protein -4 and -5 (SFRP4, 5) are negative regulators of the ...

کلیدواژه‌ها
Secreted frizzled-related proteins, DNA methylation, Acute myeloblastic leukemia, Hypermethylation