Clinical and Pathophysiologic Significance of MRI Identified Bone Marrow Lesions Associated with Knee Osteoarthritis
نویسندگان
1 Rothman Institute at Thomas Jefferson University, Philadephia, PA, USA
2 Cooper Bone and Joint Institute at Cooper Medical School of Rowan University, Camden, NJ, USA Oliashirazi Institute at Marshall University, Huntington, WV, USA Rothman Institute at Thomas Jefferson University, Philadelphia, PA, USA
3 Oliashirazi Institute, Marshall University, Huntington USA
4 Oliashirazi Institute, Marshall University, Huntington, USA
5 Medcare Orthopedics and Spine Hospital, Dubai, UAE
doi
10.22038/abjs.2019.37344.1985چکیده
Knee osteoarthritis (OA) affects the joint beyond just the articular cartilage. Specifically, magnetic resonance imagingidentifiedbone marrow lesions (BML) in the subchondral bone have both clinical and pathophysiological significance.Compared to joint space narrowing on traditional radiographs, the presence of BMLs has been better correlated withseverity of clinical symptoms as well as clinical deterioration. Presence of a BML increases the likelihood for progressionto a total knee arthroplasty by up to nine fold. Histochemical analysis of BMLs has shown increased levels of tumornecrosis factor-alpha, matrix metalloproteinases and substance P, thought to stimulate pain receptors in osteoarthritis.
