فهرست نشریات علمی دسترسی آزاد ایران

BACKGROUND: Depression is a disorder of the brain, a state of low mood and aversion to activitythat can affect a person’s thoughts, behavior, feelings, and sense of well‑being and can causealteration in sympathetic activity of the body, thus affecting heart rate variability (HRV).AIM: The study was conducted to determine the effects of depression on HRV parameters in clinicallyknown cases of depression.MATERIALS AND METHODS: A cross‑sectional (observational) study was conducted on fifty knownpatients of depression, aged 18–65 years, and fifty healthy, age‑matched, normal controls. HRV testwas conducted, and the results were analyzed statistically using Student’s “t”‑test for equal variance,for various parameters.RESULTS: The study showed that the differences in mean R‑R interval(s), mean HR (beats/min),very low frequency (VLF) power (milliseconds squared [ms2]), and low frequency/high frequency(LF/HF) power (%) (LF/HF ratio) among controls and cases were statistically highly significant, whilethe differences in LF power (ms2) in controls and cases were statistically significant. However, thedifferences in basic anthropometric parameters, STD (standard deviation of the normal to normal)(s),root mean square successive difference (ms), NN50 (count), pNN50 (%), VLF peak (Hz), LF peak (Hz),HF peak (Hz), HF power (ms2), VLF power (%), LF power (%), HF power (%), LF power (nu), andHF power (nu) were found to be statistically insignificant.CONCLUSION: Depression leads to changes in autonomic control of the body and changes theautonomic balance in favor of an increased sympathetic tone, which can be detected with fairaccuracy with HRV analysis.