فهرست نشریات علمی دسترسی آزاد ایران

INTRODUCTION: Hemophagocytic lymphohistiocytosis (HLH) is caused by overactivation ofimmune system. Gene mutations, infections, malignant, and autoimmune trigger the developmentof the disease.MATERIALS AND METHODS: Clinical data and peripheral blood samples of 21 patients suspected ofHLH were collected in Shiraz Medical Centers 2017–2018. Peripheral blood samples were analyzedfor soluble interleukin‑2 receptor alpha (sIL2Rα) marker (sCD25), and the results were comparedwith 36 normal controls as well as comparison with clinical findings and other laboratory parameters.RESULTS: Twenty‑one patients (11 males and 10 females) with an average age of 5.2 wereinvestigated. In this study, peripheral blood samples were taken from 16 newly diagnosed patientsbefore treatment, and five were posttreatment blood samples. The mean sIL2Rα level beforetreatment in 16 patients was 9023 pg/ml. The mean peripheral blood sample of the 36 controls was3025 pg/ml. The mean of the five posttreatment samples was 4198 pg/ml. Significant differencebetween pretreatment and the control group was observed. However, no significant difference wasdetected between after treatment samples and the control group. By comparing the sIL2Rα levelsbetween patients with increased aspartate aminotransaminase (AST) and patients with normal ASTlevel, there was a significant difference in the amount of IL2Rα level.CONCLUSION: This study highlights the importance of IL2Rα marker in the diagnosis and follow‑up,during treatment and suppression. Furthermore, a significant difference with respect to AST levelrequires further investigation.