فهرست نشریات علمی دسترسی آزاد ایران

BACKGROUND AND OBJECTIVE: Data on the factors affecting long‑term mortality following astroke in Iran are scarce. The current research aimed at investigating the extent of 2‑year mortalityfollowing a stroke and the factors affecting it in the northwest of Iran.MATERIALS AND METHODS: This prospective cohort study was conducted in Tabriz, Northwestof Iran. Patients with computed tomography/magnetic resonance imaging confirmed the first‑everstroke were included in this study and followed up to 2 years. Clinical examinations, including theseverity of the stroke using the modified National Institutes of Health Stroke Scale (mNIHSS), wereconducted by a neurologist. The general characteristics, lifestyle factors, and laboratory tests werealso completed. To estimate the survival, Kaplan–Meier analysis was used; and for group comparison,the log‑rank method was applied. To identify the factors predicting 2‑year mortality, semiparametricCox regression analysis was used.RESULTS: A total of 1036 first‑ever stroke patients were included in the present study. Themortality rates of stroke in 6‑month, 1‑year, and 2‑years follow‑up periods were 31.6%, 34.5%, and38%, respectively. The two‑year mortality rate was 33.6% in ischemic and 58.7% in hemorrhagicstroke (P < 0.001). In the multivariate Cox model, variables age, type of stroke, diabetes, and severityof the stroke, according to the mNIHSS index, were identified as factors predicting 2‑year mortalityfollowing the stroke.CONCLUSION: The 2‑year mortality following acute stroke was relatively high compared to that of indeveloped countries. Implementation of secondary prevention is recommended to better managementof modifiable predictors of mortality.