Induction of catalepsy in rats by NK1 receptor antagonist and early-life maternal separation synergistically: the involvement of CRF1 receptors

نویسندگان
Ionov, Ilya ID 1
Maltseva, Lyudmila ID 2
Komikarov, Piotr ID 3
D. Krasilova, Maria ID 4
O. Lyubimova, Margarita ID 5
Morozova, Nina ID 6

1 Head, Department of Neurometabolic Analysis, Centre on Theoretical Problems in Physical and Chemical Pharmacology, Russian Academy of Sciences, Moscow, 109029, Russia

2 Centre on Theoretical Problems in Physical and Chemical Pharmacology, Russian Academy of Sciences, Moscow, 109029, Russia

3 Timpharm LTD, Moscow, 117513, Russia

4 Senior Researcher, Department of Neurology, Centre on Theoretical Problems in Physical and Chemical Pharmacology, Russian Academy of Sciences, Moscow, 109029, Russia

5 Researcher, Department of Neurology, Centre on Theoretical Problems in Physical and Chemical Pharmacology, Russian Academy of Sciences, Moscow, 109029, Russia

6 Researcher, Department of Neurology, Centre on Theoretical Problems in Physical and Chemical Pharmacology, Russian Academy of Sciences, Moscow, 109029, Russia

doi
10.32592/ajnpp.2024.11.2.103
چکیده

A lower level of brain substance P (SP) is detected in Parkinson’s disease; apparently, central SP-ergic deficiency takes place in Parkinsonian patients. The pathogenic relevance of this abnormality is unknown.  Another understudied area is the influence of early-life adversities on Parkinsonism.  Here, we hypothesized that i) simulation of central SP hypoactivity by ...

کلیدواژه‌ها
NK1 receptors, CRF1 receptors, substance P, maternal separation, catalepsy