Chronic Administration of Donepezil in Inhibitory and Spatial Learning and Memory in Male Rats
نویسندگان
1 Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
2 Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
3 Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
4 Research Center for Behavioral Disorders and Substance Abuse, Hamadan University of Medical Sciences, Hamadan, Iran.
doi
10.32598/ajnpp.4.3.310چکیده
Background: Cholinergic dysfunction is involved with age-related cognitive deficits and Alzheimer’s disease. Donepezil is a reversible acetylcholinesterase inhibitor. Objectives: The present study examined the ability of chronic supplementation with donepezil on the cognition of the healthy young rats. Materials and Methods: Twenty young male Wistar rats (140-160 g) were divided into ...
