Differential Effects of Sildenafil (Viagra) on Processing Steps of Spatial Learning and Memory in Rat
نویسندگان
1 Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, IR Iran
2 Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, IR Iran
3 Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, IR Iran
4 Department of Biology, Islamic Azad University, Hamadan Branch, Hamadan, IR Iran
doi
10.17795/ajnpp-18671چکیده
Background: Sildenafil (Viagra) has been introduced to treat erectile dysfunction by acting as phosphodiesterase 5 inhibitor and hence accumulation of guanosine cyclic monophosphate (cGMP). On the other hands, the nitric oxide/cGMP signaling pathway has crucial role in synaptic plasticity processes like long-term potentiation (LTP) in the central nervous system considered as a model ...
