Synergy of Somatostatin – substance P Receptors Antagonists in the Initiation of Catalepsy in Rats

نویسندگان
Ionov, Ilya ID 1
Krasilova, Maria ID 2
Pushinskaya, Irina ID 3
Gorev, Niсholas ID 4
Tulchinskiy, Victor ID 5
Gabov, Sergey ID 6

1 Department of Neurometabolic Analysis, Centre on Theoretical Problems in Physical and Chemical Pharmacology, Russian Academy of Sciences, Moscow, Russia

2 Department of Neurometabolic Analysis, Centre on Theoretical Problems in Physical and Chemical Pharmacology, Russian Academy of Sciences, Moscow, Russia

3 Department of Neurometabolic Analysis, Centre on Theoretical Problems in Physical and Chemical Pharmacology, Russian Academy of Sciences, Moscow, Russia

4 Department of Neurometabolic Analysis, Centre on Theoretical Problems in Physical and Chemical Pharmacology, Russian Academy of Sciences, Moscow, Russia

5 Department of Neurometabolic Analysis, Centre on Theoretical Problems in Physical and Chemical Pharmacology, Russian Academy of Sciences, Moscow, Russia

6 Timpharm LTD, Moscow, Russia

doi
10.32592/ajnpp.2024.11.3.126
چکیده

The parkinsonian brain undergoes a decrease in levels of somatostatin (SST) and substance P (SP). According to previous studies, brain SST deficit in rats simulated by i.c.v. injections of SST receptor antagonist, cyclosomatostatin (cSST), increases the speed of catalepsy development. Nevertheless, it is not clear how the SP, a natural ligand of neurokinin-1 (NK1) ...

کلیدواژه‌ها
somatostatin, substance P, catalepsy, Parkinsonian disorders.