Histamine Potentiates Cyclosomatostatin-Induced Catalepsy in Old Rats
نویسندگان
1 Centre on Theoretical Problems in Physical and Chemical Pharmacology, Russian Academy of Sciences, Moscow, Russia
2 Research Group, Timpharm Ltd, Moscow, Russia
doi
10.17795/ajnpp-31238چکیده
Background: The decreased level of somatostatin and increased level of histamine are detected in the Parkinsonian brain. In old Wistar rats, the brain somatostatin deficiency can initiate catalepsy that suggests the pathogenic significance of this abnormality in Parkinson’s disease (PD). The ability of histamine to affect the somatostatin deficiency action is ...
