A Case Report: The Effects of Photobiomodulation Therapy and Amniotic Fluid Gel on a Severe Diabetic Foot Ulcer: Combination of PBMT and amniotic gel and diabetic wound
نویسندگان
1 Department of Biology and Anatomical Sciences, Shahid Beheshti University of Medical Sciences (SBMU), Tehran, Iran
2 Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences (SBMU), Tehran, Iran
3 Department of Anatomical Sciences, Zanjan University of Medical Sciences, Zanjan, Iran
4 Department of Biology and Anatomical Sciences, Shahid Beheshti University of Medical Sciences (SBMU), Tehran, Iran
5 Department of Biology and Anatomical Sciences, Shahid Beheshti University of Medical Sciences (SBMU), Tehran, Iran
6 Department of Neonatology, Mofid Children’s Hospital, Shahid Beheshti University of Medical Sciences (SBMU), Tehran, Iran
7 ProNeuroLIGHT LLC, Arizona, USA
8 Price Institute of Surgical Research, University of Louisville, and Noveratech LLC, Louisville, KY, USA
9 Endometriosis Research Center, Iran University of Medical Sciences, Tehran, Iran
10 Rehabilitations Sciences Research Center, Zahedan University of Medical Sciences, Zahedan, Iran
11 Department of Surgery, School of Medicine, Shahid Beheshti University of Medical Sciences (SBMU), Tehran, Iran
doi
43982چکیده
Introduction: Diabetic patients frequently experience a serious complication known as impaired wound healing, which increases the likelihood of foot infection and limb amputation. Investigators have been looking for novel methods to treat diabetic foot ulcers (DFUs) recently.Case Report: A 75-year-old woman with type one diabetes mellitus (DM) has been accepted. There was a sizable (40 cm2 full-thickness cutaneous wound) in the plantar part of her right foot (Wagner Ulcer Grade Classification System: grade 3) which had not been treated by the usual treatment for DFUs. In this present case, we used amniotic fluid gel (AF gel) and photobiomodulation therapy (PBMT) (400 mW/cm2 ; 810 nm, once a week for 16 weeks) to treatand speed up the healing of a harsh DFU. The size of the ulcer area significantly decreased as combination therapy progressed, and within 16 weeks, the wound was healed and the pain was reduced.Conclusion: This revealed contextual analysis demonstrated the useful effect of the mix of PBMT and AF gel on a serious DFU. To confirm the findings, we recommend conducting additional clinical trials in a clinical setting. In addition, it is recommended that additional research using preclinical models uncover the mechanism of action of the combination therapy.
