Effect of Low-Level Laser Therapy on Differentiation and Proliferation of Human Dental Pulp Stem Cells: A Systematic Review: Effect of LLLT on pulp stem cells
نویسندگان
1 Department of Endodontics, Dental Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
2 Department of Pharmacology and Toxicology, Faculty of Pharmacy, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran
3 Department of Epidemiology, School of Health Research Center for Health Sciences Health Sciences & Technology Research Institute, Hamadan University of Medical Sciences, Hamadan, Iran
4 Department of Endodontics, Dental School, Hamadan University of Medical Sciences, Hamadan, Iran
5 Department of Endodontics, Dental School, Hamadan University of Medical Sciences, Hamadan, Iran
6 1. Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran 2.Department of Endodontics, School of Dentistry, Kurdistan University of Medical Sciences, Sanandaj, Iran
doi
41742چکیده
Introduction: Considering the positive impact of laser treatment on the proliferation of certain cell types, we opted to perform a systematic review aimed at evaluating the effects of laser therapy and photobiomodulation on the proliferation and differentiation of human dental pulp stem cells (hDPSCs).Methods: We included all research studies examining the impact of laser therapy on hDPSCs, without limitations on publication dates or article languages. The major international databases, including PubMed, ISI Web of Science, and Scopus, were searched from inception to April 2022 by the relevant keywords.Results: In total, 1886 studies were identified in the initial search from the mentioned databases and other sources. Finally, 17 relevant studies were included in the present systematic review after removing duplicates and non-relevant articles. The results indicated the useful effect of low-level laser therapy (LLLT) on the hDPSCs.Conclusion: The findings of this systematic review indicate the useful role of LLLT in cell therapy, proliferation, and differentiation associated with hDPSCs.
