Collagen Synthesis as a Prominent Process During the Interval between Two Laser Sessions: Collagen synthesis as a prominent process in laser therapy
نویسندگان
1 Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2 Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3 Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4 1. Genomic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran 2. Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
5 Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
6 1.Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran 2. Iranian Cancer Control Center (MACSA), Tehran, Iran
7 Traditional Medicine and Materia Medica Research Center, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
8 Laser application in medical sciences research center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
doi
42996چکیده
Introduction: Many people suffer from skin photodamage, especially photoaging. The application of a laser to repair damages is a common therapeutic method that is used widely. In the present study, the effectiveness and molecular mechanism of an Er: Glass non-ablative fractional laser on the human skin was assessed via bioinformatics and network analysis.Methods: The gene expression profiles of 17 white female forearm skins which received an Er: Glass non-ablative fractional laser before and after laser treatment in two sessions were extracted from Gene Expression Omnibus (GEO). Data were evaluated via GEO2R and the significant differentially expressed genes (DEGs) were assessed via protein-protein interaction (PPI) network analysis. The central nodes were identified and discussed for the compared set of samples.Results: Five classes of samples were clustered in two categories: first, baseline, 7 and 14 days after the first session of laser treatment, and second, one day after the first laser session, 29 days after the first laser session, and 1 day after the second laser session. The gross cell functions such as cell division cell cycle and immune response were highlighted as the early affected targets of the laser. Collagen synthesis resulted after the first laser session.Conclusion: In conclusion, the time interval between laser sessions plays a critical role in the effectiveness of laser therapy. Findings indicate that the gross effect of laser application appears in a short time, and important processes such as collagen synthesis happen later.
