Liver and thyroid profile in educating smokeless tobacco users and its role in oral health promotion
نویسندگان
1 Department of Oral Medicine and Radiology, Orthodontics and Dentofacial Orthopaedics
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5 Prosthodontics, Crown and Bridge, Esthetic Dentistry and Oral Implantology, Dental Institute, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India
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doi
چکیده
BACKGROUND: Smokeless tobacco (SLT) usage contributes about 40% of the total tobacco usedin India. Among the 28 known carcinogens in SLT, tobacco‑specific nitrosamines are considered tobe the most potent. This has challenged the metabolic condition leading to a rise in the inflammatorystatus, hepatic injury, and apoptosis of the liver and thyroid tissues. Therefore, the present study wasundertaken to evaluate the adverse effects of SLT on the liver and thyroid and establish a correlationbetween them in Jharkhand population.MATERIALS AND METHODS: A total of 100 individuals (50 SLT users and 50 healthy individuals)were selected for the study. A complete history was obtained, and clinical examination was done toevaluate any oral mucosal changes. Venous blood samples were taken to analyze the liver functiontest and thyroid profile.RESULTS: Significant changes were observed in the liver enzyme levels and thyroid profile in SLTusers when compared to healthy controls. All the parameters of liver function test had a positivecorrelation with the form of SLT, whereas thyroid profile had a negative correlation.CONCLUSION: This study might be helpful in creating awareness on the hazards of using SLT amongthe Indian population as a despicable substitute to smoking tobacco. It also acts as a diagnostic tooland warning alarm in chronic tobacco users.
