Autoimmune Parkinsonism: A Newer Manifestation of Contactin-Associated Protein-Like 2 Autoimmunity: A Case Report
نویسندگان
1 Department of Neurology, Pinnacle Hospitals, Visakhapatnam, Andhra Pradesh, India
2 Consultant Neurosurgeon, Dr. Rajesh Neuro & Trauma Centre, Visakhapatnam, Andhra Pradesh, India
3 Department of Psychiatry, Government Hospital for Mental Care, Visakhapatnam, Andhra Pradesh, India
4 Department of Neurosurgery, Pinnacle Hospitals, Visakhapatnam, Andhra Pradesh, India
5 Department of Internal Medicine, Medicover Hospitals, Visakhapatnam, Andhra Pradesh, India
doi
43272چکیده
Contactin-associated protein-like 2 (CASPR2) antibodies are part of an expanding spectrum of disorders. Although they were initially associated with Morvan’s syndrome and peripheral nerve hyperexcitability, their clinical manifestations are more varied than previously recognized. In this report, we present a rare case of a middle-aged woman who experienced gait disturbances, sleep disturbances, behavioral changes, and postural abnormalities over a period of five months. A thorough examination revealed a Parkinsonian phenotype. Considering the timeline and symptomatology, an autoimmune work-up was conducted, which detected CASPR2 antibodies in the patient’s serum. Treatment with high-dose intravenous Methylprednisolone followed by rituximab effectively reversed her clinical manifestations without residual neurological deficits.
