Factors Associated With Neurological Manifestations in Patients With COVID-19: Neurological Manifestations of COVID-19.
نویسندگان
1 Rajaei Clinical Research Development Center, Alborz University of Medical Sciences, Karaj, Iran
2 Department of Neurology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran. & Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran
3 Department of Neurology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran
4 Department of Neurology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran
5 Alborz University of Medical Sciences, Karaj, Iran
6 Rajaei Clinical Research Development Center, Alborz University of Medical Sciences, Karaj, Iran
7 Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran
8 Department of Neurology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran
9 Alborz University of Medical Sciences, Karaj, Iran
10 Department of Electrical Computer Engineering, Texas A&M University, College Station, TX, USA
11 Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
12 Department of Internal Medicine, School of Medicine, Firoozgar General Hospital, Iran University of Medical Sciences, Tehran, Iran
doi
36667چکیده
Background: The coronavirus disease 2019 (COVID-19) is the most terrible pandemic of a respiratory disease that we had in the past century. Most existing studies explore different manifestations in COVID-19. Few recent studies have described neurological manifestations of patients with COVID-19 but their associations with age, laboratory findings, and mortality rates have not been explored well.Methods: This case-control study includes 263 patients with COVID-19 without neurological symptoms (control group) and all patients with COVID-19 with the central nervous system symptoms (n = 460, case group) hospitalized between February 2020 and April 2020. Data on demographic factors, medical history, symptoms, and laboratory tests, all are extracted from medical records.Results: Out of 723 patients with confirmed SARS-CoV-2 infection, 460 (63.6%) were identified to have at least one neurological manifestation. The mean ages of patients with and without neurological manifestation were 60.6 ± 18.0 and 60.8 ± 15.7 years, respectively. The most common symptoms were myalgia (41%), headache (20.3%), and loss of consciousness (LOC) (16.5%). Women were more likely to develop a neurological manifestation (P = 0.001). Moreover, smoking history was significantly more in patients with neurological manifestations (P = 0.03). Also, we compared two groups in terms of tracheal intubation. The need for tracheal intubation was 19% and 12% in patients with and without neurological manifestations, respectively. Furthermore, the prevalence of intensive care unit (ICU) admission was 28% and 24% in patients with COVID-19, with and without neurological manifestations, respectively. Some of the neurological manifestations such as LOC, limbs weakness, and seizure might need more ICU admission and tracheal intubation. The frequency of comorbidities and the laboratory test results were almost similar between the two groups.Conclusion: Myalgia, headache, and LOC were the most common neurological manifestations and their distributions varied depending on age. Only a few neurological manifestations were related to mortality and morbidity rates, while some of them occurred in mild cases.
