فهرست نشریات علمی دسترسی آزاد ایران

Objectives Pleomorphic adenoma is the most common benign salivary gland tumor. Since the studies conducted on the histopathology of pleomorphic adenoma have different results and this tumor can mimic other salivary gland tumors, and due to the high prevalence of this lesion, this study was conducted to investigate the clinical and histopathological differences of pleomorphic adenoma in the major and minor salivary glands. Methods A total of 72 cases with the diagnosis of pleomorphic adenoma were reviewed by the oral and maxillofacial pathologists, and the findings were analyzed using Fisher's Exact and Pearson chi-square tests to compare the frequency distribution of variables between major and minor salivary gland lesions with the first type error of 0.05. Results The most common age group was 41-50 years old, and the gender preference was for women. The clinical symptoms were mostly painless swelling. The most common locations for the major and minor salivary glands were in the parotid and in palate, respectively. The most common histopathological classification was classic; and the most common cells observed in the major and minor salivary glands were squamous and plasmacytoid, respectively. The most common microscopic pattern was solid, the most common stromal subtypes in the major and minor salivary glands were myxoid and hyalinized, respectively; and the most common capsular forms in the major and minor salivary glands were thin and partial, respectively. Keratin pearls were observed in both major and minor salivary gland lesions. Conclusion The findings of this study are consistent with previous studies in many cases. Osteoid and fatty changes in stroma were seen in this study which are remarkable findings. Partial encapsulation is more common in minor salivary glands, which could be associated with recurrence.