فهرست نشریات علمی دسترسی آزاد ایران

Objectives Periodontitis is a multifactorial disease in terms of etiology, including microbial, environmental, systemic, and genetic factors, and the host's immune response causes periodontal destruction. The present study was done to investigate the association between rs4986790 polymorphism of the TLR4 gene with chronic periodontitis in an Iranian population. Method The present case-control study was conducted on 120 people, including two groups of control (n=66) and patient (n=54) in 2022. A periodontist evaluated the periodontal condition of the people, 5 milliliters of blood sample was taken from participants, gene sequence was determined using the PCR-RFLP method, and statistical analysis was performed using the chi-square test to determine the association between the disease and the mentioned polymorphism. Results 64 participants (53.33%) were male, and the rest were female. The frequency of the A allele was 89% in the patient group and 90% in the control group, and the frequency of the G allele was 11% in the patient group and 10% in the control group. Also, the frequency of AA and AG genotypes was 78% and 22% in patients, and 80% and 20% in the control group, respectively (P=0.65). There was no statistically significant association between the genders, the presence of a specific allele or genotype with the occurrence of the disease. The odds ratio (OR) of the developing periodontitis in the heterozygous group compared to the homozygous group was calculated to be 0.78% (P=0.65). Conclusion There was no association between TLR-4 gene polymorphism and chronic periodontitis in the studied population. Keywords TLR4 Receptor; Chronic periodontitis; Single nucleotide polymorphism