Eco-friendly synthesis of new pyrimidothiazines and pyrimidooxazines using Ag/Fe3O4/SiO2@MWCNTs magnetic nanocomposites as an effective catalyst
نویسندگان
1 Department of Phthisiatry and Pulmonology, Microbiology, Virology and Immunology, Andijan State Medical Institute, Andijan, Uzbekistan.
2 Tashkent State Technical University, Tashkent, Uzbekistan.
3 Department of Children Diseases, Pediatrics, Tashkent State Medical University, Tashkent, Uzbekistan.
4 Department of Theory and Practice of German Language, Andijan State Institute of Foreign Languages, Andijan, Uzbekistan.
5 Chair of Communal and Occupational Hygiene, Fergana Medical Institute of Public Health, Fergana, Uzbekistan.
6 Department of Russian Linguistics, Chirchik State Pedagogical University, Chirchik, Uzbekistan.
7 Department of Preschool and Primary Education, Termiz University of Economics and Service, Termez, Uzbekistan.
8 Department of Propedeutics of Children's Diseases, Samarkand State Medical University, Samarkand, Uzbekistan.
9 Department of Otorhinolaryngology, Bukhara State Medical Institute named after Abu Ali ibn Sino, Bukhara, Uzbekistan.
10 Department of Transport Systems, Urgench State University named after Abu Raykhan Beruni, Urgench, Uzbekistan.
doi
10.22034/crl.2026.573813.1786چکیده
The synthesis of Ag/Fe3O4/SiO2@MWCNTs magnetic nanocomposites aimed to generate novel pyrimidothiazines and pyrimidooxazines at elevated yields. These new compounds were synthesized using a multicomponent reaction in aqueous conditions including aldehydes, urea or thiourea, dimedone, electron-deficient acetylenic chemicals, and tert-butyl isocyanide. It is important to highlight that the leaf water extract of Petasits hybridus was utilized multiple times in these methods to illustrate the reusability of the nanocatalyst and to produce the high-performance nanocatalyst. The NH group, evaluated by two procedures, imparts antioxidant capabilities to recently produced pyrimidines. The antibacterial efficacy of newly synthesized pyrimidine derivatives was evaluated by a disk diffusion method involving two distinct strains of Gram-negative bacteria and Gram-positive bacteria, indicating that these chemicals inhibited bacterial proliferation. This approach facilitates the synthesis of pyrimidine derivatives, providing advantages such as rapid reactions, high yields of final products, and ease of catalyst and product separation.
