فهرست نشریات علمی دسترسی آزاد ایران

Tuberculosis (TB) remains a considerable global health concern, particularly due to the emergence of drug-resistant strains, necessitating the continued exploration of novel therapeutic agents. In this study, the antitubercular potential of the synthesized triazole compounds against Mycobacterium tuberculosis (MTB) H37Rv was evaluated using the Microplate Alamar Blue Assay (MABA). The results demonstrated notable inhibitory activity among the tested compounds, with compound 5B exhibiting the highest potency, with a minimum inhibitory concentration (MIC) of 3.125 µg/mL, compared to standard drugs such as isoniazid (MIC: 0.05 µg/mL), rifampicin (MIC: 0.1 µg/mL), and ethambutol (MIC: 1.56 µg/mL). Other derivatives, including 1B (MIC: 12.5 µg/mL), 5D (MIC: 12.5 µg/mL), and 6C (MIC: 12.5 µg/mL), exhibited moderate inhibitory activity. These findings highlight 5B as a promising lead candidate for further drug development. Furthermore, all the synthesized triazole derivatives were structurally characterized using Infrared Spectroscopy (IR), Nuclear Magnetic Resonance (NMR), and Mass Spectrometry (MS). Although developing effective anti-tuberculosis therapies remains challenging, the findings of this study provide valuable insights into the potential of triazole-based compounds. Overall, this study establishes a strong foundation for future investigations aimed at developing safe and effective anti-tubercular agents, ultimately contributing to the reduction of TB-related morbidity and mortality.