Solubility determination and thermodynamic modeling of deferiprone in the binary aqueous mixtures of 2-propanol from 293.15 to 313.15 K: Deferiprone dissolution in the aqueous mixtures of 2-propanol
نویسندگان
1 Student Research Committee, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran. and Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
2 Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran. and Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
3 Grupo de Investigaciones Farmacéutico-Fisicoquímicas, Departamento de Farmacia, Universidad Nacional de Colombia, Sede Bogotá, Cra. 30 No. 45-03, Bogotá D. C., Colombia.
4 Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran. and Faculty of Pharmacy, Near East University, PO BOX: 99138 Nicosia, North Cyprus, Mersin 10, Turkey.
doi
10.22037/ijps.v19i4.43600چکیده
In the current work, solid-liquid equilibrium measurements and data correlations of deferiprone in 2-propanol + water were carried out. Mathematical models (van’t Hoff, λh, modified Wilson, Jouyban-Acree, and Jouyban-Acree-van’t Hoff) were utilized for correlating the experimental solubility data, and their accuracy was computed by mean relative deviation of the back-calculated data. Furthermore, the apparent thermodynamic parameters of the deferiprone dissolution process were computed by the Gibbs and van’t Hoff equations to analyze the solubility behavior in the investigated mixtures. The results from the analysis and testing of deferiprone solubility data were expected to assist crystallization processes, industrial production, and formulation research.
