The Selective Cytotoxicity of The Hydroalcoholic Extract of Santalum Album Linn Wood on A375 and SK-MEL-3 Human Malignant Melanoma Cells: Cytotoxicity Effect of White Sandal Wood Extract
نویسندگان
1 Department of Traditional Pharmacy, School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran
2 Department of Toxicology and Pharmacology, Faculty of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran
3 Department of Traditional Pharmacy, School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran
4 Department of Toxicology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
5 Department of Toxicology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
6 Dept. of Pharmacology and Toxicology, Faculty of Pharmacy, Shaheed Beheshti University of Medical Sciences, Valiasr Ave., Tehran, Iran
doi
10.22037/ijps.v18.42139چکیده
Melanoma is the cause of most skin cancer all around the world because of its high proliferation rate, metastatic nature, and limited effective therapies. According to the rapid increment in its incidence compared to other types of skin cancers, new therapies are seemed to be essential. Natural remedies can be used to treat many diseases, including cancer, so more research is needed. The wood of Santalum album Linn, known as “white sandalwood”, is one of the herbs which is a rich source of antioxidants that can be used as a therapeutic medication in different types of cancers, especially skin cancer. This research aimed to verify the cytotoxic effects of white sandalwood on A375 and SK-MEL-3 melanoma and AGO-1522 normal human fibroblast cell lines. At first, the ethanolic extract was prepared. Then, cell viability and cytotoxic activities were evaluated. Furthermore, ROS formation, lipid peroxidation, and release of cytochrome-c were also assessed. Herb extract significantly increased the death of A375 and SK-MEL-3 melanoma cells (p < 0.001), lipid peroxidation (p < 0.01), and reactive oxygen species (p < 0.01) and cytochrome c concentration (p < 0.001). Meanwhile, the same amount was ineffective and safe on AGO-1522 normal fibroblast cells. The extract of white sandalwood has considerable cytotoxic effects on the human melanoma cell line. Further studies are required to demonstrate the therapeutic effects of white sandalwood on melanoma cancer.
