فهرست نشریات علمی دسترسی آزاد ایران

Background and Objective: Lead poisoning has harmful effects on various body organs. Coenzyme Q10 (COQ10) plays a decisive role in many biological activities, such as intracellular antioxidant protection. Apoptosis is expressed and regulated in the liver by the mfn1 and mfm2 family genes. We aimed to investigate the effect of COQ10 gastric gavage on the expression of these genes in the liver of lead-infected rats. Materials and Methods: Twenty-four male rats weighing 160-210 grams were randomly divided into three groups. The control group received deionized water. The intervention groups received either 1 mg/L lead dissolved in acetic acid or q mg/K pbcl12 lead table salt dissolved in acetic acid plus 10 mg/kg COQ10 for 28 days. The expression of mfn1 and mfn2 genes were investigated by the real-time polymerase chain reaction (PCR) method. Results: The expression of mfn1 mRNA at a dose of 1 mg/L in the group receiving lead significantly decreased compared with the control group (P<0.05). In the group receiving lead+COQ10, a significant increase was seen in mfn1 expression compared with the lead group (P<0.05). The mRNA expression of the mfn2 gene at a dose of 1 mg/L lead significantly decreased in the group receiving lead compared with the control group (P<0.05). The mRNA expression of the mfn2 gene significantly increased at a dose of 1 mg/L lead and 10 mg/kg COQ10 in the group receiving lead+COQ10 compared with the lead group (P<0.05). Conclusions: Lead induces apoptosis by reducing the expression of antiapoptotic genes mfn1 and mfn2, while COQ10 increases their expression.