Exploring the Protective Effect of Ascorbic Acid and AqueousExtract of Spirulina platensison Methotrexate-Induced Lipid Peroxidation: Antioxidant effect of Spirulina platensis
نویسندگان
1 Division of Pharmaceutical Chemistry, Himalayan Pharmacy Institute, Majhitar, Rangpo, EastSikkim, 737 136, India
2 Division of Pharmaceutical Chemistry, Department of Pharmaceutical Technology, JadavpurUniversity, Kolkata 700 032, India
3 Division of Pharmaceutical Chemistry, Department of Pharmaceutical Technology, JadavpurUniversity, Kolkata 700 032, India
doi
10.22037/ijps.v3.41025چکیده
This study was designed to explore the protective effects of ascorbic acid andwater extract of Spirulina platensis(blue green algae) on methotrexate-induced lipidperoxidation using goat liver as the lipid source. This in vitroevaluation was doneby measuring the malondialdehyde, 4-hydroxy-2-nonenal, reduced glutathione andnitric oxide content of tissue homogenates. The study reveals the lipid peroxidationinduction capacity of methotrexate, the anti-peroxidative potential of ascorbic acidand aqueous extract of S. platensison methotrexate-induced lipid peroxidation.
