Histopathologic Findings of Olfactory Mucosa in COVID-19 Patients
نویسندگان
1 1. Chronic Respiratory Disease Research Center, National Research Institute of Tuberculosisand Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 2. Department of Otolaryngology, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2 Chronic Respiratory Disease Research Center, National Research Institute of Tuberculosisand Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
3 1. Chronic Respiratory Disease Research Center, National Research Institute of Tuberculosisand Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 2. Department of Otolaryngology, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
4 Chronic Respiratory Disease Research Center, National Research Institute of Tuberculosisand Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
5 Chronic Respiratory Disease Research Center, National Research Institute of Tuberculosisand Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
6 1.Hearing Disorders Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 2Department of Otolaryngology, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 3.Chronic Respiratory Disease Research Center, National Research Institute of Tuberculosisand Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.   Â
7 Critical Care Quality Improvement Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
8 Virology Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
9 1. Chronic Respiratory Disease Research Center, National Research Institute of Tuberculosisand Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 2. Department of Otolaryngology, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
10 1. Chronic Respiratory Disease Research Center, National Research Institute of Tuberculosisand Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 2. Department of Otolaryngology, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
doi
10.22037/orlfps.v9i1.42792چکیده
Background: Olfactory manifestations are common findings during the course of COVID-19, while exact physiopathology is not known Aim: We review histological changes of the nasal olfactory mucosa in COVID-19 non-survivors who died in the ICU. Methods: Sampling was done within 1 hour of death under direct vision. Specimens were taken medial to the middle turbinate in the cribriform area and embedded in paraffin blocks and stained by haematoxylin and eosin. Results: The most frequent histologic finding was the infiltration of inflammatory cells mostly comprised of lymphocytes. Inflammatory infiltration of mucosa was seen in all 11 patients with ulceration in 9 cases and neuritis in 3 cases. Conclusion: Inflammatory infiltration of olfactory mucosa may be associated with smell manifestations. Further histological studies will clarify the role of the nasal mucosa in the physiopathology of COVID-19 especially olfactory involvement.
