Trehalose increase proliferation and decrease apoptosis in hair cells induced by Hydrogen peroxides
نویسندگان
1 1 Hearing disorders research center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 2.Department of Biology and Anatomy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2 Hearing Disorders Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
3 Department of Biology and Anatomy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
4 Hearing Disorders Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
doi
10.22037/orlfps.v6i1.32486چکیده
BACKGROUND: Hydrogen peroxide (H2O2) a key reactive oxygen species, which is made through redox procedure, can induce oxidative damage to several biological macromolecules and play critical role in neurodegenerative diseases. Aim: The current study examined the neuroprotective effect of Trehalose on hair cells death induced by H2O2. Material and method: Hair cells were co-treated by Trehalose and H2O2. The effects of Trehalose on BAX/BCL2 expression ratio and cell viability were assessed by Real time PCR and MTT assay, respectively. Result: The results of Real time PCR and MTT assay indicated that H2O2 induce cell death, and Trehalose have neuroprotective effect and decreases cell death. Conclusion: Our data showed that Trehalose has the protective effect on hair cells death induced by H202
