Cell Therapy in Hearing Loss Treatment: A Review of Recent Advances
نویسندگان
1 Hearing Disorders Research Center, Loghman Hakim Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2 Hearing Disorders Research Center, Loghman Hakim Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
3 Hearing Disorders Research Center, Loghman Hakim Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
4 Hearing Disorders Research Center, Loghman Hakim Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Department of Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
5 Hearing Disorders Research Center, Loghman Hakim Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Department of Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
6 Hearing Disorders Research Center, Loghman Hakim Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
7 Hearing Disorders Research Center, Loghman Hakim Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
8 Cellular and Molecular Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.
9 Hearing Disorders Research Center, Loghman Hakim Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
doi
10.22037/orlfps.v5i1.27283چکیده
Background: The mammal's inner ear is responsible for hearing and balance. To perform these tasks, it requires the vestibular and cochlear system. Sensor neural hearing loss (SNHL) is the most common type of hearing loss resulting in degeneration of internal sensory hair cell, where cochlear nerve in cochlear stem cell and gene-based strategies provide the opportunity for replacement for these cells.Aim: In this review, we evaluated the efficiency of stem cell therapy in inner ear.Methods: In this study we examined different articles in different databases such as Google Scholar, PubMed, and Elsevier.Results: The stem cells have offered desired results in the delivery of gene and tissue engineering programs. Evidence suggests that stem cells are considered as a promising tool in medical applications thanks to their high plasticity and trophic characteristics.Conclusion: In this review, Stem cell transplantation is widely used in clinical practice, and the source is highly desirable, since the patient's bone marrow cells can be potentially transplanted without any safety problems.
