The impact of poor glycemic control on lipid profile variables in children with type 1 diabetes mellitus
نویسندگان
1 Community and Family Medicine Department, Isfahan University of Medical Sciences, Isfahan University of Medical Sciences
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5 Pediatric Pulmonology, Isfahan University of Medical Sciences, Isfahan, Iran
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doi
چکیده
BACKGROUND: Type 1 diabetes mellitus (T1DM) and its related comorbidities are considered animportant health issue. This study aimed to evaluate the impact of glycemic control on lipid profilevariables in children with T1DM.MATERIALS AND METHODS: This study included 274 children (≤19 years of age) with T1DM whohad referred to the outpatient clinics of endocrinology in Emam‑Hossein Hospital of Isfahan, Iran.Based on American Diabetes Association criteria, patients were divided into two groups includingoptimal glycemic control (OGC) and poor glycemic control (PGC). Mean lipid level and frequenciesof lipid profile abnormalities between the two studied groups were compared.RESULTS: Mean age of the studied population was 13 ± 5.9 years and 133 (48.5%) were boys. A totalof 162 (59.1%) and 112 (40.9%) patients had PGC and OGC, respectively. Hypercholesterolemia wasthe most common dyslipidemia in both groups (33 [29.1%] of OGC and 63 [39.1%] of PGC patients).The frequency of high low‑density lipoprotein (LDL) was significantly higher in patients with PGCthan those with OCG (P = 0.007). The frequencies of hypercholesterolemia, hypertriglyceridemia,and low levels of high‑density lipoprotein were also higher in PGC group, but did not reach thesignificant threshold.CONCLUSION: It is suggested that glycemic control is in association with lipid profile abnormalityin patients with T1DM. High LDL was significantly more frequent in patients with PGC than thosewith OGC. It is recommended to investigate the role of glycemic control on other cardiometabolicrisk factors of T1DM patients. Our findings could be used for planning preventative strategies forreducing T1DM‑related cardiovascular disease.
