فهرست نشریات علمی دسترسی آزاد ایران

AbstractBackgroundPemphigus is a rare and potentially life-threatening disease. It produces blisters in the skin andmucous membranes. In more than 81% of cases, pemphigus involves oral mucosa. This studyassessed the efficacy of mouthwash with honey compared with hydrogen peroxide on oral lesionshealing in Pemphigus patients.Materials and methodsA randomized design clinical trial was carried on 49 patients with oral pemphigus lesions. Patientsrandomly divided into experimental and control groups. Patients were assessed for 10 days. Datawere collected by questionnaire, Oral Mucositis Visual Assessment Guide of WHO, visual analogscale of pain intensity and time Diaries.ResultsAge, sex, educational level, marital status, history of crisis in the past 6 months, history ofautoimmune disease and history of pemphigus disease in their family, were not statisticallysignificant differente in experimental (honey mouthwash) and control (hydrogen peroxidemouthwash) groups. Degree of oral lesions faster was improved in experimental (honey mouthwash)group compared with control (hydrogen peroxide mouthwash) group. Reducing pain intensity in theexperimental group was significant from the third day(P = 0.001), while it was not statisticallysignificant in the control group until the tenth day of assessment.ConclusionHoney mouthwash compared with hydrogen peroxide has had faster effect on oral lesions healingand more effective on reducing pain in pemphigus patients. Honey mouthwash has no complicationin this group of patients.Key words: pemphigus, oral lesions, honey, Hydrogen peroxide