Effectiveness of Quercus brantii hydroalcoholic extract on dyspepsia: A randomized, double blind clinical trial
نویسندگان
1 Gastrointestinal and Hepatobiliary Diseases Research Center, Poursina Hakim Research Institute for Health Care Development, Isfahan,
2 Department of Internal Medicine, School of Medicine, Yasuj University of Medical Sciences, Yasuj
3 Molecular Clinical Microbiology Subdivision, Clinical Pathology Division, Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Clinical Education Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
doi
چکیده
CONTEXT AND AIMS: We aimed to evaluate the effectiveness of hydroalcoholic extract of Quercusbrantii’s nut on clinical, endoscopic, and pathological findings of patients with dyspepsia.PATIENTS AND METHODS: In this randomized, double-blind clinical trial, patients with symptomaticdyspepsia who had an endoscopic evaluation for dyspepsia were included and randomized into twogroups. One Group (A) received drug extract with a dose of 100 mg twice a day for 10 days. Group B,as a control group, received placebo. Immediately and 2 months after intervention, the patients werefollowed up, and the characteristics of their dyspepsia (severity and frequency), endoscopic andpathologic fi ndings were reevaluated and compared.RESULTS: In this trial, 13 and ten patients participated in the study in Groups A and B, respectively.Two months after intervention, ten (76.9%) and six (60%) participants referred for follow-upand endoscopic evaluation. There were no signifi cant changes in clinical presentations afterintervention (P > 0.05). Two months after intervention, clinical presentations including severity andfrequency of epigastric pain had signifi cant decrease in Group A and endoscopic evaluation indicatedsignifi cant improvement in Group A (P < 0.05). Pathologic fi ndings were similar and not signifi cantlydifferent in two studied groups after intervention (P > 0.05).CONCLUSIONS: The fi ndings of this trial indicated that hydroalcoholic extract of Q. brantii’s nutcould have delayed signifi cant proper effect on clinical and endoscopic presentations of patientswith dyspepsia. We recommend that this study should be considered as pilot one in this fi eld. Theresults could be used as baseline data for more interventional studies. More surveys are needed toinvestigate the mechanism of extract action at molecular basis.
