Identification of etiologic agents of cutaneous Leishmaniasis in palpebral position followed by effective therapy
نویسندگان
1 Department of Medical Parasitology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz
2 Center for Research and Training in Skin Diseases and Leprosy, Tehran University of Medical Sciences
3 Skin Diseases and Leishmaniasis Research Center, Department of Parasitology and Mycology, Isfahan University of Medical Sciences, Isfahan
4 Department of Parasitology and Mycology, Faculty of Medicine, Isfahan University of Medical SciencesSkin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran
5 Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran
6 Department of Medical Parasitology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz
doi
چکیده
CONTEXT: Cutaneous Leishmaniasis (CL) is a self‑healing lesion but prevention of complicationsand involvement of vital organs such as palpebra requires proper treatment.AIMS: The main objectives were to detect agents of CL in palpebral region and estimate the proportionof palpebral lesion also possible complications among CL patients in a zoonotic CL endemic area.SETTINGS AND DESIGN: The study was performed from April 2012 to March 2013 in a total of1613 CL suspected patients by interview and physically exam.SUBJECTS AND METHODS: The samples were used for direct smear using Giemsa stain method, orcultured in Novy‑McNeal‑Nicol medium. For further checked, nested polymerase chain reaction (PCR)was used for negative palpebral samples. Of the 1613 examined samples, 848 (81.4%) by directsmear, 188 (18%) by culture and 6 (0.6%) by nested PCR were positive, respectively. A total of 233of the patients showed lesions on the face of whom 15 (male = 5, female = 10, 1.43% of all and6.43% of facial lesions) presented with palpebral CL. The results of nested PCR indicated that allthe palpebral cases were due to Leishmania major.CONCLUSIONS: About 93% of the patients with palpebral lesion were under 5 years old and wereinfected in the hyper endemic regions, but no ocular complication was seen in any of them. Basedon the results, it seems that early referring to the medical center for proper diagnosis and treatmentis the main reason for prevention of further complications.
