Smoking history and Alzheimer’s disease risk in a community‑based clinic population
نویسندگان
1 Neurology Division, Los Angeles Biomedical Research Institute,Neurology
2 Psychiatry Division, Los Angeles Biomedical Research Institute, Departments of Psychiatry, Harbor‑UCLA Medical Center, Torrance, Departments of Psychiatry, David Geffen School of Medicine, UCLA, Los Angeles, CA 90509, USA
3 Neurology Division, Los Angeles Biomedical Research Institute
4 Neurology Division, Los Angeles Biomedical Research Institute,Neurology
doi
چکیده
BACKGROUND: The relationship between cigarette smoking and development of Alzheimer’sdisease (AD) is not fully determined, and previous reports disagree, with some studies suggestingan increased relative risk and others a decreased odds ratio. Consequently, we wanted to determineif the prevalence of past cigarette smoking observed in a community‑based clinic sample of patientswith AD would be more consistent with the expected value obtained from a model using either anincreased relative risk or a decreased odds ratio to estimate the effect of smoking on developmentof AD.MATERIALS AND METHODS: Retrospective cross‑sectional analysis of all patients treated for ADin a community‑based Neurology Clinic during a 2‑year period. Estimates of expected past smokingprevalence were calculated based on published values for either an increased relative risk or adecreased odds ratio and compared to the past smoking prevalence observed in the clinic sample.RESULTS: The observed past smoking prevalence in the clinic population was 29.17%.The expected past smoking prevalence calculated using the increased relative risk was30.07% (95% confidence interval [CI] = 27.67–32.32%), and using the decreased odds ratio was12.54% (95% CI = 6.32–24.81%).CONCLUSION: The observed past smoking prevalence among the patients being treated for ADin a community‑based clinic falls within the expected 95% CI for the increased relative risk modeland outside of the expected 95% CI for the decreased odds ratio model. These results supportthe contention that the relationship between cigarette smoking and development of AD is the bestcharacterized by an increased relative risk.
