فهرست نشریات علمی دسترسی آزاد ایران

Wide application of nanoparticles causes considerable environmental, health, and safety problems. CuO NPs have been studied for their potential agricultural applications. This systematic review followed three main steps: literature search, study selection, and data extraction. The searches were conducted in PubMed and Scopus using core keywords and synonyms. Also, VOSviewer software was used to visualize and assess bibliographic data. Our study showed that the accumulation of CuO nanoparticles in the tissues of medicinal plants can have both positive and negative effects, depending on the plant species, concentration, and exposure duration. NPs once inside plants, they allow for multiple applications, they can cross the cell membrane and enter with various organelles and biomolecules such as DNA, RNA, and proteins, and can also transport DNA and chemicals into the plant cell. Furthermore, these NPs can be taken up by plants and accumulate in various plant tissues, raising concerns about their potential impact on human health if ingested via the food chain. If copper intake exceeds the human tolerance level, it causes toxic effects such as hemolysis, jaundice, liver cirrhosis, and even death. Further research is needed to determine the safe and effective application method and optimal concentration of CuO NPs in agriculture.