Conventional Interferon Alpha Therapy of Chronic Hepatitis C in Patients with End Stage Renal Disease, Six versus Twelve Months? A Meta-Analysis

نویسندگان
doi
چکیده

Methods: : We required that studies report HCV RNA results at least 6 months after treatment cessation. Ninety-five percent confidence intervals (CI) of SVRs were calculated using the approximate normal distribution model. 95% CI of pooled SVR was computed by random effects models. Data manipulation and statistical analyses were undertaken using STATA 8.0. Results: The pooled SVR for 24 and 48 weeks of standard IFN monotherapy was 38.2% (95% CI=28.9%-47.5%) and 36.9% (95% CI=24.3%-49.4%), respectively. Pooled dropout rate was 24.2% (95% CI=9.5%-38.9%) and 26.9% (95% CI=10.6%-43.3%) in 24 and 48 weeks of IFN monotherapy, respectively. Conclusion: Standard IFN is still the drug of choice in treatment of HCV in dialysis individuals and 6 months seems to be equal to one-year duration of therapy.

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