Does Living Donor Hyperoxia Have an Impact on Kidney Graft Function After Transplantation?

نویسندگان
doi
10.5812/numonthly.11870
چکیده

Background: Improvement in the outcome of organ transplantation is related to advances in patient selection criteria, organ preservation, operative techniques, perioperative care and efficacy of immunosuppressive agents. Objectives: We aimed to evaluate the effects of higher levels of arterial PaO 2 in donors on DGF (delayed graft function). Results: Forty living kidney transplantations including 17 cases and 23 controls were performed; female gender was more prevalent in recipients (n = 16, 40%). The mean age of recipients was 36.1 ± 12.4 (18-67) years old. DGF was detected in 2 (5.95%) individuals, from whom one was in the case group and the other one in the control group. In the univariate analysis, there was no significant correlation between age and biomarkers in urine and serum unless for the second serum NGAL (P = 0.02, r = -0.06) and second urine IL 18 (P = 0.03, r = -0.5) which had a negative correlation, and first urine TNF α (P = 0.02, r = 0.7) which had a positive correlation. Conclusions: Oxygen therapy in the case group had no significant impact on protection from DGF.