فهرست نشریات علمی دسترسی آزاد ایران

Background: Vesicoureteral reflux (VUR) is a common childhood disorder that is characterized by the abnormal movement of urine from the bladder into the ureters or kidneys. Objectives: The aim of this study was to determine whether the genetic polymorphisms of the IL-10 , IL-12 , and TNF-α genes are involved in the development of VUR. Results: A significant, highly increased risk of VUR disease was found for the CA , AA , and combined genotypes of IL-10CA597 (OR = 5.2, 95% CL: 1.80 - 18.25; P = 0.0006, OR = 9.1, 95% CL: 1.11 - 122.75; P = 0.02, OR = 5.3, 95% CL: 1.82 - 18.61; P = 0.00052, respectively); the AG , GG , and AG + GG genotypes of IL-10AG-1082 (OR = 12.8, 95% CL; 2.9 - 113.9; P = 0.00003, OR = 12.62, 95% CL: 2.93 - 114.53; P = 0.00003, respectively); and the AA genotype of IL-12 ( AA , OR = 0.19, 95% CL: 0.5 - 0.55; P = 0.0006). The frequency of the C allele in both IL-10CA and IL-12CA was greater in patients with VUR than in the healthy controls. No association was found between TNF308GA and the risk of VUR. Conclusions: The results demonstrated significant associations between the IL-10 ( AG-1089 , IL-10CA ) and IL-12 (AA) gene polymorphisms and a highly increased risk of VUR.