فهرست نشریات علمی دسترسی آزاد ایران

Background : Traumatic brain injury (TBI) is a well-established risk factor for neuropsychiatric disorders. However, the relationship between lesion localization and psychiatric phenotypes remains incompletely characterized, particularly in forensic contexts. Objectives: This longitudinal study of an Iranian forensic cohort retrospective analysis of prospectively collected data aimed to investigate the frequency and pattern of psychiatric sequelae following TBI and explore associations between neuroanatomical injury sites and specific psychopathological outcomes. Methods : A total of 113 patients with documented TBI (GCS ≤14, hospitalization ≥24 hours) were consecutively recruited from the Forensic Medicine Organization of Khorasan Razavi, Iran (2020–2022). Patients underwent psychiatric evaluation over a median follow-up of 13 months (IQR: 6–18 months). DSM-5 diagnoses were established using structured clinical interviews. CT scans were reviewed for lesion localization. Multivariate logistic regression and effect sizes (Cramér's V, Cohen's h, risk ratios) were employed. Results: The cohort comprised 92 males (81.4%) and 21 females (18.6%), with a mean age of 36.5 ± 18.4 years. Traffic accidents predominated (84.1%). Notably, 41.6% of patients exhibited no focal parenchymal lesions on initial CT. The most prevalent diagnoses were neurocognitive Disorder (23.0%), major depressive Disorder (19.5%), personality change (13.3%), and post-concussion syndrome (13.3%). In this forensic cohort, 100% of participants received at least one psychiatric diagnosis, which reflects the medicolegal referral context and does not generalize to non-forensic TBI populations. Frontal lobe involvement showed a numerically higher frequency of personality change (29.4% vs. 10.5%; risk ratio = 2.80, 95% CI: 0.98–7.99; p = 0.078). Gender was not an independent predictor (adjusted OR = 1.24, 95% CI: 0.48–3.21, p = 0.66). Conclusion: Neurocognitive Disorder and major depression are the predominant psychiatric sequelae in this Iranian forensic TBI cohort. A substantial proportion of patients developed significant psychopathology despite normal CT imaging—the "normal CT paradox"—underscoring the need for psychiatric surveillance regardless of neuroimaging findings. Findings are limited to forensic medicolegal populations and do not generalize to the general TBI population.