فهرست نشریات علمی دسترسی آزاد ایران

Infertility is characterized by the failure to attain a successful pregnancy after one year of normal intercourse.  Infertility has a negative impact on the mental and psychosocial well-being of influenced couples, result to reduced quality of life. Infertility is recognized as a global health problem, plague nearly 15% of couples worldwide. It can result from female-related factors (30%), such as premature ovarian failure and uterine disease [ 1 ]. Despite recent advances in assisted reproductive technology (ART), many couples are incapable to conceive except through gamete and embryo donation or adoption [ 2 ]. Cell-based therapy for fertility restoration is an active research field in some countries. Stem cells are primitive cells found in almost all tissues. They are unspecialized cells with the ability to differentiate, self-renew and proliferate. The mechanism of stem cell function in infertility treatment is to replace injured cells and restore the structure and function of affected organs [ 3 ]. Stem cells show renewed hope in overcoming problems associated with infertility in several preclinical and clinical studies [ 4 ]. For women infertility, stem cells may be applied to regenerate ovaries, oocyte and/or endometrium [ 5 , 6 ]. This field started with a provocative publication in 2004. In this publication, endometrial biopsies from a small number of women who underwent bone marrow transplantation were examined and found donor-derived cells levels is nearly half of the epithelial and stromal cells in the biopsy samples [ 7 ].