فهرست نشریات علمی دسترسی آزاد ایران

Background: Postoperative pain in addicted patients is important because they are opioid tolerant, they have abnormal pain sensitivity and psychological disorders. Many modalities and combination of medications have been used to reduce the suffering of addicted patients’ postoperative pain. There has been some evidence for the use of antipsychotics for such pain control. Objectives: The aim of this study was to compare the effect of morphine versus morphine/haloperidol on postoperative pain management in opioid-addicted patients undergoing orthopedic surgery. Results: The trend of decrease in the pain scores between the placebo and haloperidol groups was significant (P < 0.001) with higher slope in the haloperidol group. The trend of decrease in morphine consumption between the groups was significant (P < 0.001) with higher slope in the haloperidol group. In the placebo group, at hour two, 45 patients (90%) were pain-free, whereas in the haloperidol group, 51 patients (100%) were pain-free (P = 0.027). The total morphine dosages used in the two groups had a statistically significant difference (P < 0.001). Conclusions: Haloperidol together with morphine is beneficial in postoperative pain management in opium-addicted patients.