Rethinking Neonatal Vaccination Policies: A Neuroimmune Perspective
نویسندگان
1 Department of Nuclear Medicine, Children Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran
2 Department of Neonatology, Children Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran
3 Department of Neonatology, Children Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran
4 Department of Nuclear Medicine, Children Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran
5 Department of Medical Physics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
6 Department of Nuclear Medicine, Children Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran
doi
10.30476/ijms.2025.106591.4083چکیده
Neonatal vaccination is a cornerstone of early-life infectious disease prevention. However, the timing and safety of these interventions require careful consideration. This review explored the neuroimmune implications of early immunization, with a specific focus on the interplay between the developing immune and nervous systems. We examined potential mechanisms through which vaccine-induced immune activation might influence brain development, through epigenetic modifications and sustained cytokine responses, particularly involving interleukin-6 (IL-6). The discussion addressed concerns related to immune overstimulation, regulatory T-cell suppression, and microbiome disruption, considering their potential links to autoimmune and neurodevelopmental disorders. In light of the identified evidence gaps, we advocate for a cautious, individualized vaccination approach guided by the “As Low and Late As Reasonably Achievable” (ALLARA) principle. This strategy aimed to balance robust protection against infectious diseases with the imperative of safeguarding lifelong neurological and immunological health.
